Speaker: Dr. Tania HIDALGO CRESPO (Postdoctoral Researcher at the Advanced Porous Material Unit)
Dr. Hidalgo has obtained a Joint PhD thesis in Material Chemistry & Pharmacy issued by the University of Versailles (France) and the University of Santiago de Compostela (Spain). Her PhD project was based on the synthesis and characterization of novel drug delivery systems, the nanoscaled Metal-Organic Frameworks (nanoMOFs), modulating their fate by external surface modifications with attractive biopolymers depending on the desired administration route. After her PhD, she started her postdoctoral experience with a MedTrain Marie Skłodowska-Curie COFUND Fellowship in UCC (Ireland), aimed at efficient drug delivery platforms for nucleic acid delivery across the blood-brain barrier (BBB). Currently, she has been awarded with the “Atracción del Talento” grant from the Community of Madrid in order to develop porous materials for the protection & immobilization of macromolecules. Dr. Hidalgo (H-index:6) is co-author of 7 scientific papers (published in high-impact international journals) and a book chapter.
A successful manufacturing for diverse industrial applications (such as gas storage, separation, catalysis or biomedicine) relies on the control of the physicochemical properties of a given material, determining its affinity by different structures and/or matrixes. Further, a specific formulation determines important parameters, such as toxicity, biodistribution and efficacy of a biomedical system. Among the large number of potential particles, porous materials such as organic (cyclodextrins) or hybrid (Metal-Organic Frameworks, MOFs) have been functionalized with specific external surface agents (e.g. polymers, targeted ligands). The intimate relationship between the environment and the physicochemical properties of these nanoparticles will be here explained: smart surface engineering could modulate their features as requested.
Friday, May 31, 2019
Dr. Tania HIDALGO CRESPO
Auditorium, IMDEA Energy Institute