Cancer is still one of the high-societal concerned severe disease over the world. Novel strategies such as targeted delivery of genetic material has emerged as promising therapeutic approach since they are able to modulate/inhibit the progression of tumoral cells.
Among diverse drug delivery systems, nanoscaled metal-organic frameworks (nanoMOFs) have been proposed as an original and biocompatible therapeutic prototype. In this work*, we have demonstrated
- the successful loading of active nucleic acid inside nanoMOFs, ensuring its protection,
- its efficient cell internalization and
- its effective in vitro activity through the successful tumoral modification.
In short, these promising outcomes pave the way for developing original & efficient nanoMOF-based gene delivery platforms.
(*) Hidalgo, T., Alonso-Nocelo, M., Bouzo, B.L., Reimondez-Troitiño, S., Abuin-Redondo, C., De La Fuente, M., Horcajada, P. (2020) Nanoscale, 12 (8), pp. 4839-4845. publication