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Would be possible to govern the particle motion?

The new MSCA-IF 2019 approach at IMDEA Energy

Advanced Porous Materials Unit (APMU) at IMDEA Energy Institute is composed by experts in the synthesis and characterization of a new class of porous hybrid materials, known as Metal-Organic Frameworks (MOFs), whose application has attracted a growing interest from both academic and industrials in relevant fields (energy, health and environment). Precisely, multifunctional materials for adsorption & catalysis is one of the innovative research lines of this group, where Dr. Tania Hidalgo is investigating about the protection & immobilization of macromolecules using MOFs.

Dr. Tania Hidalgo has been recently awarded with the prestigious Marie Skłodowska Curie Individual Fellowship (NeuroMOF H2020-MSCA-IF-2019: “Self-propelled Metal-Organic Framework nanocarriers as promising brain delivery platform”). This project is addressing a challenging objective: the presence of the blood-brain barrier (BBB) severely constrains drug delivery to the brain, limiting the treatment of neurological diseases.

In this context, NeuroMOF proposes the development of a biosafe and efficient tailored drug delivery system (DDS) based on nanoscaled porous Metal Organic Frameworks (nanoMOFs) for brain delivery. To achieve this goal, two original targeting strategies will be undertaken: MOF targeting & MOF motion (self-propelled nanomotors) through a suitable macromolecule immobilization. The most promising nanometric MOF prototypes will be selected based on the outcomes achieved on the biodistribution, biocompatibility and bioactivity assays performed on in vitro and in vivo BBB models. 

This highly innovative research will open new avenues for the bio & technological application of nanoMOFs, promoting the development of innovative approaches for targeting more effective neurological therapies.

Researchers: Tania Hidalgo (H-index: 10) & Patricia Horcajada (H-index: 55), Advanced Porous Materials Unit, IMDEA Energy, Móstoles-Madrid, Spain.
Collaborators: Giuseppe Battaglia (H-index: 47), Molecular Bionics Lab, University College London (London, UK) & Institute for Bioengineering of Catalonia (Barcelona, Spain).
Acknowledgement: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 897678.

More information: Tania Hidalgo, Postdoctoral Researcher, Advanced Porous Materials Unit, tania.hidalgo@imdea.org

Event Date: 
Wednesday, April 29, 2020