A wide range of active pharmaceutical ingredients targets the skin for therapeutics or cosmetic purposes. Since ancient times, topical delivery has been considered as a route for the delivery of pharmaceuticals. Skin diseases can be treated both by topical and oral medications. As advantage, the topical ones prevent the side effects of systemic absorption of orally administered drugs. Among all the reported drugs, azelaic acid (AzA - antimicrobial and anti-inflammatory agent), and nicotinamide (Nic - antiacne drug) have recently emerged as promising treatments of common skin disorders. However, repeated or high doses (AzA) are required to achieve the desired effects, or suffer from poor skin retention and permeation (Nic), reducing their effectiveness and use.
Combined therapies emerge as an interesting tool to overcome these limitations (efficacy, side effects). Among other materials, metal-organic frameworks (MOFs) offer versatilities for the accommodation of multiple and complementary drugs: accessible large porosity, availability of functionalization sites, and biocompatibility.
Here*, we have prepared a topical formulation (i.e. patch) based on porous iron carboxylate MOFs co-encapsulating the two complementary drugs (AzA and Nic) and a biopolymer (polyvinyl alcohol), in order to develop an advanced cutaneous combined therapy. The prepared MOF-based patches are biosafe and maintain the high drugs-loading capacity (total drugs content between 24 and 40 wt.%), while allowing a progressive delivery of their cargoes, permeating through the skin to the active target site. The total amount of drug retained or diffused through the skin is within the range (Nic), or even better (AzA) than commercial formulations currently available. These results open an avenue for the development of new cutaneous devices for skin therapy.
(*) Combined Cutaneous Therapy Using Biocompatible Metal-Organic Frameworks. Seyed Dariush Taherzade, Sara Rojas, Janet Soleimannejad, Patricia Horcajada. Nanomaterials, 2020, 10, 2296; https://www.mdpi.com/2079-4991/10/12/2296
More information: Patricia Horcajada, Senior researcher and head of the Advanced Porous Materials Unit, firstname.lastname@example.org
Biocompatible metal-organic frameworks as platforms for combined cutaneous therapy