Although the extended use of conventional oral and intravenous treatments, other alternative therapies like the pulmonary administration of drugs have been developed in the last years. Lungs are a very attractive target for local and systemic delivery of drugs, to treat not only local pulmonary but also non-pulmonary diseases. The pulmonary route presents several advantages: 1) lungs have a large and highly vascularized surface, favouring the drug absorption, and 2) it is safe, with less adverse side effects than other administration routes. However, the pulmonary administration route presents some limitations, focus mainly on its insufficient lung penetration. In order to avoid these drawbacks, the use of nanoparticulate systems has been proposed as an interesting alternative for the development of efficient treatments.
We propose here* a pioneer formulation based on nanoscaled metal-organic frameworks (MOFs) as potential carriers for pulmonary drug administration. MOFs present several advantages as drug delivery systems: biocompatibility, exceptional porosity associated with high drug loadings, highly tuneable structures and compositions, and appropriate biological stability and particle size.
In this study, we have prepared biocompatible microspheres based on the biocompatible MOF MIL-100 and mannitol using a simple and efficient continuous spray-drying technique. These microspheres exhibit optimal properties (e.g. homogeneity, size, density, and spray-drying process yield) for their pulmonary administration. Upon their intratracheal administration to animals, the microspheres are uniformly dispersed along the lungs, reaching the bronchioles and alveoli.
(*) Metal−Organic Framework Microsphere Formulation for Pulmonary Administration. Cristina Fernández-Paz, Sara Rojas, Pablo Salcedo-Abraira, Teresa Simón-Yarza, Carmen Remuñán-López, Patricia Horcajada. ACS Applied Materials & Interfaces, 2020, 12, 23, 25676-25682. https://pubs.acs.org/doi/10.1021/acsami.0c07356
More information: Patricia Horcajada, Senior researcher and head of the Advanced Porous Materials Unit, firstname.lastname@example.org
Metal−Organic Framework Microsphere Formulation for Pulmonary Administration.