The first bioinspired microporous metal−organic framework (MOF) based on a common natural antioxidant and polyphenol building unit, the ellagic acid as main linker source, with a biocompatible and antimicrobial cation, Bi3+, has been here outlined for the first time*. Appointed as SU-101 [Bi2O(H2O)2(C14H2O8)·nH2O] is entirely composed from non-hazardous or edible reagents, affordable as dietary supplements (tree bark and pomegranate hulls sources) developed under scalable, green and ambient synthesis aqueous conditions. Their biocompatibility and colloidal stability have been confirmed by in vitro assays under biorelevant conditions. The material has also exhibited remarkable chemical stability for a bioinspired MOF (pH = 2−14, hydrothermal conditions, heated organic solvents, biological media, SO2 and H2S), attributed to the strongly chelating phenolates, which is considered suitable features for environmental and biological applications such as depollution or drug delivery.
As evidence thereof, we have recorded one of the highest H2S uptake obtained for a MOF particle, classified as one of the most hazardous air pollutants by the World Health Organization.
Thefore, phenolic phytochemicals remain largely unexplored as linkers for MOF synthesis, opening new avenues to design stable, eco-friendly, scalable and low-cost MOFs for environmental and health applications.
(*) Erik Svensson Grape, J. Gabriel Flores, Tania Hidalgo, Eva Martínez-Ahumada, Aída Gutiérrez-Alejandre, Audrey Hautier, Daryl R. Williams, Michael O’Keeffe, Lars Öhrström, Tom Willhammar, Patricia Horcajada, Ilich A. Ibarra, and A. Ken Inge. J. Am. Chem. Soc. 2020, 142, 16795−16804. https://doi.org/10.1021/jacs.0c07525
More information: Tania Hidalgo, Postdoctoral researcher, Advanced Porous Material Unit, firstname.lastname@example.org
The structure of SU-101 as viewed down the c-axis.